Journal of Pharmacovigilance

Nworu CS

Publications

• Research Article
  Unregulated Promotion and Sale of Herbal Remedies: A Safety and Efficacy Evaluation of Twelve Such Commercial Products Claimed to be Beneficial and Patronised for a Variety of Ailments in Nigeria
  Author(s): Nworu CS, Vin-Anuonye T, Okonkwo ET, Oyeka CO, Okoli UB, Onyeto CA, Mbaoji FN, Nwabunike I and Akah PANworu CS, Vin-Anuonye T, Okonkwo ET, Oyeka CO, Okoli UB, Onyeto CA, Mbaoji FN, Nwabunike I and Akah PA
  
  Preparation, distribution, advertisement, and usage of phythomedicinal products in Nigeria are weakly regulated raising genuine concern for public safety. In this study, twelve highly patronised commercial herbal products (S1- S12) claimed to be beneficial in the management of either diabetes mellitus, diarrhoea, or hypertension were procured from herbal vendors in Nigeria and evaluated against their claims of efficacy and safety using established whole animal and in vitro models. S1, S2, and S3 were tested for anti-hyperglycaemic activity in normoglycemic and diabetic rats and only S1 and S2 showed some reductions in blood glucose at some time points but S3 produced no reduction in blood sugar at all the time points. Three samples, S4, S5, and S6 significantly (P ≤ 0.05) inhibited the frequency of diarrhoea drops in rats at a dose of 250 mg/kg and caused minimal (P>0.05) reduct.. View More»
  DOI: 10.4172/2329-6887.S1-002

  Abstract PDF