Pharmaceutica Analytica Acta

Najma Sultana

Publications

• Research Article
  Spectrophotometric Studies of Lamotrigine Charge Transfer Complexes:Synthesis and Characterization
  Author(s): Najma Sultana, Saeed Arayne M and Saeeda Nadir AliNajma Sultana, Saeed Arayne M and Saeeda Nadir Ali
  
  Charge transfer complexes of lamotrigine with 7,7,8,8-tetracyanoquinodimethane, bromothymol blue and picric acid have been investigated by spectrophotometric method. Optimum conditions for the reactions and validation data is reported. Resulting complexes absorb at 394, 404 and 374 nm in the Beer’s law range of 0.15-15, 0.25- 10 and 3.0-18 µg mL-1 with correlation coefficient greater than 0.998 in each case and detection limits 45, 47 and 57 µg mL-1 respectively. The data are discussed in terms of molar absorptivity, association constant and Gibb’s free energy. Spectral characteristics including oscillator’s strength, dipole moment, ionization potential, energy of complexes and resonance energy have been determined. Benesi-Hildebrand plots for each complex have been constructed. The proposed method was applied successfully for the de.. View More»
  DOI: 10.4172/2153-2435.1000260

  Abstract PDF