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Journal of Bioequivalence & Bioavailability

Naga Supriya Grandhi

Publications
  • Research Article
    Simultaneous Determination of Rosuvastatin and Ezetimibe in pharmaceutical formulations by Stability Indicating Liquid Chromatographic Method
    Author(s): Mathrusri Annapurna Mukthinuthalapati, Venkatesh Bukkapatnam, Sai Pavan Kumar Bandaru and Naga Supriya GrandhiMathrusri Annapurna Mukthinuthalapati, Venkatesh Bukkapatnam, Sai Pavan Kumar Bandaru and Naga Supriya Grandhi

    Rosuvastatin and Ezetimibe are used for the treatment of hyperlipidemia. A stability-indicating RP-HPLC method was developed and validated for the simultaneous determination of Rosuvastatin and Ezetimibe in tablet dosage forms using C 18 column with mobile phase consisting of tetra butyl ammonium hydrogen sulphate-acetonitrile (32:68, v/v) with a flow rate of 1.0 ml/min (UV detection 254 nm). Linearity was observed over the concentration range 0.1-200 μg/ml for both Rosuvastatin (r2=0.9998) and Ezetimibe (r2=0.9998). The LOD and LOQ were found to be 0.0282 μg/ml and 0.0853 μg/m for Rosuvastatin and the LOD and LOQ for Ezetimibe were 0.0297 μg/ml and 0.0901 μg/ml respectively. Rosuvastatin and Ezetimibe were subjected to stress conditions of degradation in aqueous solutions including acidic, alkaline, oxidation, photolysis and thermal degradation. Ezetimibe is highly sen.. View More»
    DOI: 10.4172/jbb.1000200

    Abstract PDF