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Mohammad Saeid Hejazi
Mohammad Saeid Hejazi
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz,
West Indies
Publications
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Research Article
Riboswitches as Potential Targets for Aminoglycosides Compared with rRNA Molecules: In Silico Study
Author(s): Elnaz Mehdizadeh Aghdam, Mohammad Esmaeil Hejazi, Mohammad Saeid Hejazi and Abolfazl BarzegarElnaz Mehdizadeh Aghdam, Mohammad Esmaeil Hejazi, Mohammad Saeid Hejazi and Abolfazl Barzegar
Riboswitches are cis acting riboregulaters in non-coding region of the mRNAs. Their possible contribution in antibiotic targeting especially for FMN, TPP and lysine riboswitches in bacteria has been revealed since a decade ago. Regarding some studies on the possibility of the interaction between aminoglycosides and the artificial riboswitches, in this study we attempted to evaluate the binding potential of different types of aminoglycosides including gentamicin, amikacin, kanamycin, neomycin, tobramaycin, sisomicin and paromomycin with various classes of riboswitches using computational methods. Applying Auto Dock vina, it was shown that the binding energy of each kind of riboswitches with different types of aminoglycosides (riboswitches/aminoglycosides) is almost similar or sometimes more than .. View More»
DOI: 10.4172/1948-5948.S9-002