Journal of Liver

Minjie Chen

Publications

• Research Article
  Quantification of Hepatic Lipid Using 7.0T Proton Magnetic Resonance Spectroscopy and Computed Tomography in Mild Alcoholic Steatotic Mice
  Author(s): Qi Cao, Su Xu, Shujing Li, Minjie Chen, Xicui Sun, Yamin Wan, Liya Pi, Zhekang Ying and Bin RenQi Cao, Su Xu, Shujing Li, Minjie Chen, Xicui Sun, Yamin Wan, Liya Pi, Zhekang Ying and Bin Ren
  
  Background: In vivo proton magnetic resonance spectroscopy (1H MRS) has been used to semi-quantify hepatic lipids in preclinical and clinical studies of fatty liver disease. Quantifying absolute amount of liver lipids utilizing 1H MRS and computerized tomography (CT) is essential to accurately interpret hepatic steatosis. Purpose: To establish reliable parameters to convert relative hepatic lipid levels obtained by 1H-MRS and liver volumes by CT to the absolute amount of liver lipids in a mild hepatic steatosis, and to determinate the correlation between these absolute liver lipids with liver triglyceride (TG) and cholesterol (Chol) measured by biochemistry assays. Methods: Mild steatosis was induced in mice by a 3 week ethanol diet containing standard lipids. Evaporated liver wa.. View More»
  DOI: 10.4172/2167-0889.1000234

  Abstract PDF