Journal of Blood Disorders & Transfusion

Matthew J Simmonds

Publications

• Review
  CALR and CD47: An Insight into Their Roles in the Disease Progression of MDS and MPN
  Author(s): Kristian Boasman, Matthew J Simmonds and Ciro R RinaldiKristian Boasman, Matthew J Simmonds and Ciro R Rinaldi
  
  Myelodysplastic syndrome and myeloproliferative neoplasms are clonal myeloid disorders arising from haematopoietic stem cells that have the tendency to progress into acute myeloid leukaemia. Multiple prognostic scoring systems have been proposed and utilised in clinical practice to predict disease evolution, however none of them can predict treatment response. In solid tumours, the relationship between the pro-phagocytic calreticulin and the anti-phagocytic CD47 is repeatedly investigated. Overexpression of calreticulin has been documented to produce a pro-phagocytic signal in solid tumour and it is often counteracted by a concomitant expression of the antiphagocytic CD47 as they act in response to one another, reflecting an apoptosis vs survival mechanism in response to chemotherapy. The role of both calreticulin and CD47 are currently poorly understood in .. View More»
  DOI: 10.4172/2155-9864.1000413

  Abstract PDF