Journal of Allergy & Therapy

Matthew J. Budoff

Publications

• Research Article
  Effect of Testosterone and Resistance Training on Cardiac Mass and Contractility in Men with COPD
  Author(s): Matthew J. Budoff, Songshou Mao, Mehdi Rambod, Ronald J. Oudiz and Richard CasaburiMatthew J. Budoff, Songshou Mao, Mehdi Rambod, Ronald J. Oudiz and Richard Casaburi
  
  Introduction: Testosterone therapy and resistance training have been demonstrated to improve muscle mass and strength in patients with testosterone deficiency. However the effects on cardiac mass and contractility of these interventions have not been identified in prospective placebo-controlled trials. The hypothesis of this trial was that resistance training and testosterone replacement would improve cardiac mass and contractility in male COPD patients with low testosterone levels. Methods: We conducted a 10 week trial in a 2 by 2 factorial design, randomizing 53 patients to replacement doses of testosterone enanthate (100 mg weekly) or placebo, as well as to a program of lower extremity resistance training or no exercise. We performed rest and exercise cardiac computed tomography (CCT) studies before and after 10 weeks of therapy to evaluate right and left heart function. Pa.. View More»
  DOI: 10.4172/2155-6121.S2-001

  Abstract PDF