Journal of Stem Cell Research & Therapy

Martina Maass

Publications

• Research Article
  Gelatine Microspheres Support Direct Intramyocardial Delivery of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
  Author(s): Raja Ghazanfar Ali Sahito, Carlos O Heras-Bautista, Benjamin Krausgrill, Martina Maass, Sven Baumgartner, Jurgen Hescheler, Agapios Sachinidis and Kurt PfannkucheRaja Ghazanfar Ali Sahito, Carlos O Heras-Bautista, Benjamin Krausgrill, Martina Maass, Sven Baumgartner, Jurgen Hescheler, Agapios Sachinidis and Kurt Pfannkuche
  
  Objective: Cardiac cell replacement therapy (cellular cardiomyoplasty) aims at restoring contractile function following cardiac infarction or cardiac myopathy and may add a new option to conventional treatments of cardiac failure in the future. Currently, this approach is hampered by the minor rate of cell engraftment and optimal strategies and routes of cell delivery need to be identified. Delivery of cardiomyocytes immobilized on biodegradable microspheres could support cell transfer.  Methods: Murine induced pluripotent stem cell derived cardiomyocytes (iPS-CMs) expressing puromycinacetyltransferase and enhanced green fluorescent protein (eGFP) under control of the Acta-2 promotor were used. Macroporous gelatine microspheres were loaded with single cell suspensions of purified iPS-CMs and transplanted into healthy murine myocardial t.. View More»
  DOI: 10.4172/2157-7633.1000306

  Abstract PDF