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Maria Antonietta Panaro
Maria Antonietta Panaro
Department of Scienze Mediche di Base, University of Bari, P.zza G. Cesare, 11, I-70124 Bari,
Italy
Publications
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Research Article
MAP Kinases are Required for Apoptosis of HCT-8 Epithelial Cells Induced by the Parasite Giardia intestinalis
Author(s): Pasqua Cavallo, Antonia Cianciulli, Rosa Calvello, Teresa Dragone and Maria Antonietta PanaroPasqua Cavallo, Antonia Cianciulli, Rosa Calvello, Teresa Dragone and Maria Antonietta Panaro
Giardia intestinalis is a protozoan that causes a generally self-limited clinical illness typically characterized by diarrhea, abdominal cramps, bloating, weight loss and malabsorption. The pathogenesis of giardiasis is multifactorial and probably different in various animal models, but the mechanisms responsible for the disease are still poorly understood. We previously reported that G. intestinalis is able to induce apoptosis in the human HCT-8 epithelial cell line through the activation of both the intrinsic and extrinsic apoptotic pathways. In the present study we demonstrate that activation of the mitogen-activated protein kinases (MAPKs) plays an important role in the regulation of HCT-8 cell apoptosis induced by G. intestinalis. MAPK activation seems to correlate with regulation of the apoptotic process because specific MAPK inhibitors significantly reduced the expression of th.. View More»
DOI: 10.4172/1948-5948.1000068