Journal of Stem Cell Research & Therapy

Marek Dobke

Publications

• Research Article
  Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)
  Author(s): Meenakshi Gaur, Lu Wang, Alexandra Amaro-Ortiz, Marek Dobke, I. King Jordan and Victoria V LunyakMeenakshi Gaur, Lu Wang, Alexandra Amaro-Ortiz, Marek Dobke, I. King Jordan and Victoria V Lunyak
  
  MSC mediate numerous therapeutic effects by promoting repair directly via differentiation into critical cell types or indirectly through the secretion of a broad spectrum of soluble factors with diverse paracrine activities. However, recent discoveries indicate that MSC are sensitive to endogenous and exogenous stressors and many diseaserelated interventions can result in Therapy-Induced Senescence (TIS) in MSC. Here, we provide a detailed analysis of changes in secretory factors that occur under conditions of bleomycin treatment that triggers genotoxic stressinduced senescence of Human Adipose-Derived Stem Cells (hADSCs). The bleomycin treatment considerably alters the composition of hADSCs secretome. Our data reveal the novel unique composition of Senescence Messaging Secretome (SMS) of hADSCs and suggest that this SMS might critically influence genotoxic drug-based or MSC combinati.. View More»
  DOI: 10.4172/2157-7633.1000396

  Abstract PDF