Journal of Bioequivalence & Bioavailability

Mahipal Reddy Donthi

Publications

• Research Article
  Preparation and Evaluation of Fixed Combination of Ketoprofen Enteric Coated and Famotidine Floating Mini Tablets by Single Unit Encapsulation System
  Author(s): Mahipal Reddy Donthi, Narendar Reddy Dudhipala, Devendhar Reddy Komalla, Dinesh Suram and Nagaraju BanalaMahipal Reddy Donthi, Narendar Reddy Dudhipala, Devendhar Reddy Komalla, Dinesh Suram and Nagaraju Banala
  
  Ketoprofen is a non steroidal anti inflammatory drug and famotidine is a H2 receptor antagonist. The patients with immune mediated diseases like rheumatoid and osteo arthritis treated with ketoprofen, which induces ulcers in the stomach by the stimulation of H2 receptor and inhibition of COX-I enzyme. Upon the addition of famotidine suppress the acid secretion in the stomach, this mechanism was implemented by the delivery system at different time periods with different site specificity in the GIT and drug release was programmed according to the pH dependent solubility and also includes reducing the cost. Hence, the content of this investigation was to prepare and evaluate the famotidine floating and ketoprofen enteric coated mini tablets capsulated in a single unit dosage form. The tablets were prepared by wet granulation method using HPMC K100M and HPMC K15M as release controlling po.. View More»
  DOI: 10.4172/jbb.1000254

  Abstract PDF