Journal of Stem Cell Research & Therapy

LuZhe Sun

Biography

Dr. LuZhe Sun received his Ph.D. degree in Physiology from Rutgers-The State University of New Jersey and UMDNJ-Robert Wood Johnson Medical School in 1990 and obtained his postdoctoral training in Baylor College of Medicine in the US. He became an independent researcher in 1995 as Tenure-track Assistant Professor of Pharmacology in the University of Kentucky School of Medicine and is currently Professor of Cellular and Structural Biology, Dielmann Endowed Chair in Oncology, and Associate Director for Translational Research at the Cancer Treatment and Research Center in the University of Texas Health Science Center. Dr. Sun’s research is focused on investigating molecular mechanisms of tumorigenesis and metastasis, and novel experimental therapeutics in various models of carcinomas in the past two decades. He participated in the discovery of the tumor suppressor role of TGFβ type II receptor in hereditary non-polyposis colorectal cancer and pioneered the use of a soluble TGFβ type III receptor and the engineer of a soluble chimeric TGFβ receptor for the inhibition of cancer growth, angiogenesis, and metastasis in various preclinical models of human cancers. Currently, his laboratory is investigating various cellular signaling pathways, particularly the hormonal signaling and TGFβ signaling pathways, in driving cancer development, growth, and metastasis, and the effect of environmental compounds and aging on the function, genomic integrity, and susceptibility to transformation of mammary stem cells. His research has been supported with multi-million dollar funding from National Institutes of Health, Department of Defense, Cancer Prevention and Research Institute of Texas, the University of Texas Health Science Center, and other private foundations. He has served as chartered member of Cancer Biomarker Study Section, and Tumor Progression and Metastasis Study Section of NIH and has regularly been invited to participate in grant review panels by NIH and DOD. Dr. Sun has published over 80 peer-reviewed manuscripts.

Research Interest

His research intersted areas are TGF-beta signaling ,Mammary stem cell function , Cell cycle, tumor metastasis, Breast cancer ,Prostate cancer.