Cardiovascular Pharmacology: Open Access

Luiz Cesar Guarita-Souza

Publications

• Short Communication
  Isoproterenol-Induced Intramural Cytotoxicity Does Not Correlate with Echocardiographic Functional Abnormalities in Wistar Rat Hearts
  Author(s): Luciane Filla, Julio Cesar Francisco, Rossana Baggio Simeoni, Nelson Itiro Myiague, Ana Carolina. Irioda, Reginaldo Justino Ferreira, Marcia Olandoski, Luiz Cesar Guarita-Souza, Eltyeb Abdelwahid and Katherine Athayde Teixeira de CarvalhoLuciane Filla, Julio Cesar Francisco, Rossana Baggio Simeoni, Nelson Itiro Myiague, Ana Carolina. Irioda, Reginaldo Justino Ferreira, Marcia Olandoski, Luiz Cesar Guarita-Souza, Eltyeb Abdelwahid and Katherine Athayde Teixeira de Carvalho
  
  Background: Isoproterenol (ISO) is a potent non-selective beta-adrenergic agonist with very low affinity for alpha-adrenergic receptors used for treatment of various cardiac problems including ventricular arrhythmias, asthma and shock. In addition, ISO is also used postoperatively after cardiac surgery. The aim of this study was to analyze the association between histopathological and functional effects of ISO in the rat myocardium. Methods: 24 Wistar rats (healthy, males) were used in these experiments. The animals were randomly divided two groups. Group I (n=12): all animals received ISO subcutaneous administration (0,3 mg/Kg/day for 8 days). Group II (n=12): all animals received Phosphate Buffered Saline (PBS) subcutaneous administration as a control. One day after drug administration has been completed; echocardiographic analysis of cardiac function was performed. Histopathologica.. View More»
  DOI: 10.4172/2329-6607.1000165

  Abstract PDF