Journal of Tumour Research & Reports

Lesley Guo

Publications

• Research Article
  Low Rate of Subsequent Whole Brain Radiotherapy Following a Policy of Local Therapy with MRI Surveillance for Central Nervous System Oligometastases
  Author(s): Georgia Harris, Raymond Cook, Charles Teo, Dasantha Jayamanne, Lesley Guo and Michael BackGeorgia Harris, Raymond Cook, Charles Teo, Dasantha Jayamanne, Lesley Guo and Michael Back
  
  Background: Palliative Whole Brain Radiotherapy (WBRT) for cerebral metastases has potential morbidity and in large randomized studies has not shown a clear survival benefit. This study audits the outcome of patients with cerebral oligometastatic disease (which we defined as 1-4 lesions on MRI) who were managed with an active policy avoiding WBRT utilising local therapies and MRI surveillance. Methods: A clinical audit was performed of 31 patients with cerebral oligometastases referred for radiation therapy at the Northern Sydney Cancer Centre between July 2009 and December 2012. Patients were offered management with a programme of local therapy (neurosurgery, stereotactic radiosurgery or intensity modulated radiotherapy, or combined modality therapy) followed by protocol based MRI surveillance. Systemic therapy was delivered as indicated for extra-cranial disease. Data on pat.. View More»
  DOI: 10.4172/2475-3203.1000110

  Abstract PDF