Journal of Carcinogenesis & Mutagenesis

Laurent Ramont

Publications

• Review Article
  Control of Tumor Progression by Extracellular Matrix Molecule Fragments, the Matrikines
  Author(s): Jean Claude Monboisse, Jean Baptiste Oudart, Stéphane Brezillon, Bertrand Brassart, Laurent Ramont, François Xavier Maquart and Sylvie Brassart-PascoJean Claude Monboisse, Jean Baptiste Oudart, Stéphane Brezillon, Bertrand Brassart, Laurent Ramont, François Xavier Maquart and Sylvie Brassart-Pasco
  
  Tumor microenvironment is a complex system composed of a largely altered Extracellular Matrix (ECM) with different cell types that determine tumor progression. Upon the influence of hypoxia, tumor cells secrete cytokines that activate stromal cells to produce proteases and angiogenic factors. The proteases degrade the stromal ECM and participate in the release of various ECM fragments, named matrikines or matricryptins, capable to control tumor invasion and metastasis dissemination. The putative targets of the matrikine action are the proliferation and invasive properties of tumor or inflammatory cells, and the angiogenic and lymphangiogenic responses. In the present review, we will describe pro-tumorigenic effects triggered by soluble elastin or Elastin-Derived Peptides (EDPs), as well as the anti-tumorigenic or anti-angiogenic activities the matrikines derived from basement membrane.. View More»
  DOI: 10.4172/2157-2518.1000148

  Abstract PDF