Journal of Next Generation Sequencing & Applications

Laura A Zahavich

Publications

• Research Article
  An Inherited Arrhythmia Syndrome with Long QT, Sudden Death and Depolarization Disorder Due to an In-Frame Deletion in Exon 16 of the CACNA1C Gene
  Author(s): Muhammad Arshad Rafiq, Tamara T Koopmann, Laura A Zahavich, Meena Fatah and Robert M Hamilton Muhammad Arshad Rafiq, Tamara T Koopmann, Laura A Zahavich, Meena Fatah and Robert M Hamilton
  
  Mutations of the gene encoding the L-type voltage gated calcium channel alpha-1C subunit (CACNA1C) underlie long QT phenotypes as part of Timothy syndrome. Milder phenotypes, as well as isolated cardiac phenotypes, including Brugada syndrome have been observed. To date, CACNA1C mutations have typically been missense mutations on limited number of sites that result in either gain of function (Timothy syndrome with a prolonged QT) or loss of function (short QT and/or Brugada pattern on ECG). We report a multiplex four-generation family with 3 individuals affected by QT prolongation, sudden cardiac death and conduction abnormalities, segregating with a novel heterozygous in-frame deletion mutation in exon 16 of CACNA1C resulting in a single amino acid deletion (p.Lys773del) discovered by using clinical gene panel testing at Invitae Corporation. Affected members are present in 3 consecuti.. View More»
  DOI: 10.4172/2469-9853.1000144

  Abstract PDF