Kyle A Franco
231 East Chestnut St Louisville, KY 40202
Tanzania
Research Article
Impact of Malignancy Category on Vancomycin Dosage Requirements in
Pediatric Oncology Patients
Author(s): Kyle A Franco and Tara HigginsKyle A Franco and Tara Higgins
Objectives: To determine the dosage of vancomycin in milligrams/kilogram/day (mg/kg/day) required to achieve
a trough value of 10 to 20 micrograms/milliliter (mcg/mL) in pediatric patients with differing types of malignancies.
Methods: Retrospective review of pediatric patients with hematologic malignancy, solid tumor, or status post
autologous or allogeneic hematopoietic stem cell transplantation (HSCT) receiving at least two doses of intravenous
vancomycin with at least one evaluable trough concentration. Primary outcome was the dosage of vancomycin
required to achieve first therapeutic trough value. Secondary endpoints included dosage requirement by age,
proportion of patients achieving goal, incidence of supratherapeutic trough values and nephrotoxicity.
Results: Mean dosage requirements were 72.5 [&.. View More»
DOI:
10.4172/2329-6887.1000238