Kou Hayakawa
Graduate School of Health Sciences, Gunma University, 3-39-15, Showa-machi, Maebashi, Gunma 371-8514,
Japan
Case Report
Changes in the Hydrophobic Proteins in Response to Biotin Administration in Serum of Infant Patients with Alopecia as Assessed by the Protein Micro-Sequencing Method
Author(s): Kiyomi Abe, Kou Hayakawa, Kenji Ihara, Kentaro Deguchi and Takeaki NagamineKiyomi Abe, Kou Hayakawa, Kenji Ihara, Kentaro Deguchi and Takeaki Nagamine
Introduction: In order to clarify the mechanism of hair growth induced by biotin, we compared the serum proteins before and after the oral biotin administration.
Materials and methods: The serum of three biotin-deficient children with alopecia were studied. Oral biotin administration was performed. Component proteins of serum were studied by using unique quantitative proteinmicrosequencing- deciphering method.
Results: Hydrophobic membrane-proteins of ultra-high-sulphur keratin-associated protein was detected in the serum of biotin-deficient children with alopecia. This membrane protein in the serum disappeared after the biotin administration. This phenomenon is significant (p<0.05; Mann-Whitney’s U test).
Conclusion: Biotin deficiency in.. View More»
DOI:
10.4172/1948-5948.1000179