Clinical & Medical Biochemistry

Kleanthi Dima

Publications

• Research Article
  AKT2 Gene Polymorphisms, Srankl/OPG And Hormone Measurements in Polycystic Ovarian Syndrome (PCOS) Women
  Author(s): Aikaterini Zerva, Christos Kroupis, Efthihios Trakakis, Nikoleta Poumpouridou, Marina Tsagkla, Evanthia Kassi, Dimitrios Kassanos and Kleanthi DimaAikaterini Zerva, Christos Kroupis, Efthihios Trakakis, Nikoleta Poumpouridou, Marina Tsagkla, Evanthia Kassi, Dimitrios Kassanos and Kleanthi Dima
  
  Objective: Polycystic Ovarian Syndrome (PCOS) is a common endocrinologic disorder diagnosed in 6-10% of female population at reproductive age. Altered expression of AKT2 gene has been correlated to increased insulin tolerance and reduced glucose disposal, both of which are PCOS features. The goal of this study was to investigate the association between AKT2 gene polymorphisms, serum biomarkers OPG and sRANKL as cardiovascular biomarkers, hormones (DHEAS, SHBG, testosterone, E2, LH, FSH, prolactin, insulin, 17-OH progesterone) and clinical characteristics as well (amenorrhea, oligomenorrhea, dysmenorrhea, acne, hirsutism, oily skin). Study design: A total of 60 Greek Caucasian PCOS patients and another 30 healthy women that were age- and BMI-matched, were recruited in the study and their blood specimens and clinical characteristics collected... View More»
  DOI: 10.4172/2471-2663.1000123

  Abstract PDF