Journal of Blood Disorders & Transfusion

Kensuke Umakoshi

Publications

• Review Article
  Elevation of Neutrophil Elastase Activity in Intra-Operative Recovered Shed Blood
  Author(s): Soichi Maekawa, Kensuke Umakoshi, Satoshi Kikuchi, Hironori Matsumoto, Jun Takeba, Suguru Anen, Naoki Moriyama and Mayuki AibikiSoichi Maekawa, Kensuke Umakoshi, Satoshi Kikuchi, Hironori Matsumoto, Jun Takeba, Suguru Anen, Naoki Moriyama and Mayuki Aibiki
  
  Background and Aim: Neutrophil elastase releasing from activated polymorphonuclear neutrophils (PMN) may have a central role in acute lung injury. Thus, we examined whether neutrophil elastase activity (NEA), a crucial parameter for organ damages from stresses, may increase in intra-operative recovered blood and also whether the storage duration of the bank bloods may affect such changes in NEA. Methods: In thirty-two packed red cells of bank bloods, NEAs were measured by ELISA on several day points after the storage. Intra-operative salvaged red cell concentrates (RCCs) were obtained from thirteen patients undergoing spinal surgery. The salvaged bloods from the patients were divided into two groups: NE activities in autologous RCCs obtained from eight patients were examined soon after the preparation (Group A); such activities in RCCs from five subjects were determined post-operative.. View More»
  

  Abstract PDF