Journal of Tumour Research & Reports

Kassem N

Publications

• Research Article
  A Cholesterol Derivative (Hydroxysterol; 24-Ethyl-Cholestane-3β,5α,6α-Triol) With High Antitumor Activity Against a Variety of Sarcomas
  Author(s): Nabil Habib, Hajj G, Daaboul H, Jabbour A, Zeitouni H, Khalifeh R and Kassem NNabil Habib, Hajj G, Daaboul H, Jabbour A, Zeitouni H, Khalifeh R and Kassem N
  
  Oxygenated derivatives of cholesterol, Oxysterol, have different physicochemical properties acting on cell membranes. Agents belonging to this class of compounds have been found to induce apoptosis and to harbour antitumor activity demonstrated in vitro and in vivo. 24-ethyl-cholestane- 3β, 5α, and 6α-triol is a new hydroxysterol developed in our lab. Unlike other derivatives, it is, to our knowledge, the first one tested in the clinic. We have treated eight patients suffering from different types of sarcomas with bad performance status. Three patients were suffering from carcinosarcomas, one from angiosarcoma, one from osteosarcoma, one from low-grade chondrosarcoma, one from poorly differentiated sarcoma and one from Ewing sarcoma. All of them were pre-treated with chemotherapy with or without radiotherapy. Seven patients were females and one male with ages ranging .. View More»
  DOI: 10.35248/2684-1614.18.3.118

  Abstract PDF