Journal of Pharmacovigilance

Jürgen Kornischka

Publications

• Case Report
  Acute Drug-Induced Hepatitis during Aripiprazole Monotherapy: A Case Report
  Author(s): Jürgen Kornischka, Joachim Cordes, Christina Engelke, Renate Grohmann and Marcus AgelinkJürgen Kornischka, Joachim Cordes, Christina Engelke, Renate Grohmann and Marcus Agelink
  
  Only a few case studies have been reported about antipsychotic-induced hepatitis for second generation antipsychotics. A 52-year old patient with recurrent schizoaffective psychosis was switched over from clozapine to aripiprazole monotherapy. Six weeks afterwards the otherwise asymptomatic patient presented herself with skin and scleral jaundice. Hepatic laboratory parameters and liver histological evaluation were initiated. Blood tests performed in outpatient clinic revealed significantly pathological hepatic laboratory parameters (total bilirubin 17.9 mg/dl, direct bilirubin 9.0 mg/dl, GOT 1613 U/l, GPT 2585 U/l). The liver histological evaluation shows a portal inflammatory cellular reaction with eosinophilia. After immediate discontinuation of aripiprazole medication, the elevated laboratory parameters normalised. We assume that the patient had suffered drug-induced hepatitis with p.. View More»
  DOI: 10.4172/2329-6887.1000201

  Abstract PDF