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Jerry KY Chan
Jerry KY Chan
Singapore
Publications
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Research Article
Regionally-Derived Second-Trimester Primary hfNSCs Have Different Neurogenic Capacity for Neuronal Differentiation
Author(s): Yiping Fan, Tong Zi Ping, Eyleen Goh, Mahesh Choolani and Jerry KY ChanYiping Fan, Tong Zi Ping, Eyleen Goh, Mahesh Choolani and Jerry KY Chan
Parkinson disease is a debilitating neurodegenerative disease, which is incurable and treatment has been focused on reducing the symptoms and delaying disease progression. Cellular therapy involving grafting of fetal dopaminergic (DA) neurons or fetal mesencephalic tissues rich in DA neurons has been promising. Human fetal neural Stem Cells (hfNSCs) have the potential to be an ideal cell source and hence, we aimed to investigate DA differentiation capacity of eight regionally-derived hfNSCs while defining the differences between regionally-derived hfNSCs. The differences in regionally-derived hfNSCs response to brain-derived neurotrophic factor, dopamine, forskolin and retinoic acid (DM2) or interleukin 1β and fetal bovine serum (DM1) indicated different intrinsic neurogenic potentials within the developing fetal brain. DM2 induced more efficient DA differentiation (Tyros.. View More»