Journal of Pharmacovigilance

Jean Tyrrell

Publications

• Review Article
  Gaining the Upper Hand on Pulmonary Drug Delivery
  Author(s): Jean Tyrrell and Robert TarranJean Tyrrell and Robert Tarran
  
  Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF) are all pulmonary diseases which are characterized by chronic inflammation and an increase in mucus production. Excess mucus in the airways correlates with pathophysiology such as a decline in lung function and prolonged bacterial infections. New drugs to treat these chronic respiratory diseases are currently being developed and include both inhaled and orally administered compounds. Whilst oral drugs may be easier to administer, they are more prone to side-effects due to higher bioavailability. Inhaled compounds may show reduced bioavailability, but face their own unique challenges. For example, thick mucus in the respiratory tracts of asthma, CF and COPD patients can act as a physical barrier that impedes drug delivery. Mucus also contains a high number of enzymes and proteases that may degrade compounds befo.. View More»
  DOI: 10.4172/2329-6887.1000118

  Abstract PDF