Journal of Stem Cell Research & Therapy

James L. Sherley

Biography

Dr. James L. Sherley graduated from Harvard College with a B.A. in biology in 1980 and completed joint M.D. and Ph.D. degrees at the Johns Hopkins University School of Medicine in 1988. Thereafter, at Princeton University as a post-doctoral fellow, he investigated cellular mechanisms of p53 gene growth regulation. In 1991, as a new principal investigator, Dr. Sherley continued his studies of p53 that led to his future seminal research to elucidate molecular mechanisms involved in asymmetric self-renewal by tissue stem cells. In 1998, he moved to the Massachusetts Institute of Technology where he began research to translate his discovery of p53-dependent asymmetric self-renewal into bioengineered solutions for longstanding barriers to progress in adult stem cell-based biomedicine. In 2007, Dr. Sherley joined the faculty of the Boston Biomedical Research Institute (BBRI) as a Senior Scientist to continue development of novel biotechnologies for quantifying and producing human tissue stem cells. At BBRI, he founded the Adult Stem Cell Technology Center (ASCTC); and later, after BBRI’s closure in 2013, he established this research center as a limited liability company, which he now directs. The ASCTC, LLC deploys its unique portfolio of tissue stem cell biotechnology patents to engineer processes for mass-producing human tissue stem cells for applications in drug development and transplantation medicine. Dr. Sherley has published 64 original scientific research articles, book chapters, lectures, perspectives, and reviews, as well as 34 articles in the public service of science and society education. In recognition of his research accomplishments, he received the Pew Charitable Trusts’ Scholar Award in Biomedical Science, the Ellison Medical Foundation Senior Scholar Award in Aging Research, and the National Institutes of Health Director’s Pioneer Award.

Research Interest

Elucidate molecular mechanisms involved in asymmetric self-renewal by tissue stem cells