Journal of Stem Cell Research & Therapy

James Byrne

Publications

• Research Article
  Adult Stem Cell Subsets from Human Dermis
  Author(s): Agustin Vega-Crespo, Brian Truong, Benjamen E. Schoenberg, Alexandra K. Ciminera, Benjamin L. Larson, Daniel G. Anderson and James ByrneAgustin Vega-Crespo, Brian Truong, Benjamen E. Schoenberg, Alexandra K. Ciminera, Benjamin L. Larson, Daniel G. Anderson and James Byrne
  
  Adult stem cells possess the ability to differentiate and mature into defined cell types; however, tissue-specificity and donor and culture inconsistencies have presented a challenge in identifying these cells. Adult adherent dermal cell-products have been efficiently utilized for isogenic cosmetic therapies. The purpose of this study is to identify, isolate, and characterize progenitor subsets from adult adherent dermal cells capable of ex vivo differentiation. LAVIV® adult dermal cells were independently immunoselected for CD146, CD271, and CD73/CD90/CD105 to investigate the mesenchymal differentiation capacity and possible enrichment in the purified fractions. After differentiation, the osteogenic, chondrogenic, and adipogenic potential and cell-specific gene expression were evaluated and compared for each phenotype. Adult dermal cells possess the ability to differentiate into.. View More»
  DOI: 10.4172/2157-7633.1000411

  Abstract PDF