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Iswinarno Dososaputro
Iswinarno Dososaputro
Indonesia
Publications
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Research Article
Role of Adipose-Derived Mesenchymal Stem Cells in Full Thickness Wound Healing
Author(s): Iswinarno Dososaputro, Lisette T Hoekstra, Dinar Rahmania and David S PerdanakusumaIswinarno Dososaputro, Lisette T Hoekstra, Dinar Rahmania and David S Perdanakusuma
Background: Wound healing problems can arise in donor wounds after harvesting a full-thickness graft. Returning Mesenchymal Stem Cells (MSCs) on the wounds may accelerate wound healing. The aim of this study is to analyse the effect of MSCs in the epithelialization process and collagen density on full-thickness wound healing. Methods: The pilot study included 10 patients undergoing excision of a full-thickness skin graft on the groin. Patients were randomly divided into two groups: Mesenchymal Stem Cells (MSCs) and Non-Mesenchymal Stem Cells (Non-MSCs). The MSCs group had previously undergone fat harvesting which was processed into mesenchymal stem cells. Biopsies were taken from both groups on days 14 (proliferative phase) and 45 (maturation phase), and were compared with normal skin (NS; n=5). Epithelial layers of the epidermis were assess.. View More»
DOI: 10.4172/2157-7633.1000398