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Gurudutta Gangenahalli
Gurudutta Gangenahalli
Institute of Nuclear Medicine and Allied Sciences (INMAS),
Delhi
India
Publications
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Review Article
Hematopoietic Stem Cell Molecular Targets and Factors Essential for Hematopoiesis
Author(s): Pawan Kumar Raghav and Gurudutta Gangenahalli Pawan Kumar Raghav and Gurudutta Gangenahalli
Hematopoietic Stem Cells (HSCs) gained popularity in the area of medicine because of its remarkable potential to cure an enormous range of human diseases. These stem cells are used for therapeutic purposes for its regenerative capacity and possessed hematopoiesis. This process reflects characteristic properties, proliferation, and differentiation. These behaviors are a result of protein-mediated molecular interactions. However, these molecular interactions underlying are yet to be explored. Thus, the present review focuses on the molecular basis of hematopoiesis wherein, significant molecular interactions which regulate differentiation and proliferation has been discussed. Primarily, we have addressed the role of cytokines, transcription factors, proliferation, and pathways involved in hematopoiesis. Also, relationship with multiple cytokines, small molecules, nutrients, cell-cell con.. View More»
DOI: 10.4172/2157-7633.1000441