Journal of Stem Cell Research & Therapy

Gonzalez Cadavid NF

Biography

Dr. Gonzalez-Cadavid  completed his Ph.D University of London.  He is currently working as a  Director, Urology Research Laboratory LABioMed-Harbor/UCLA. He has made significant research contributions in several fields of cellular and molecular biology approaches to pathophysiology. He focused initially on alterations of collagen deposition with aging, and later on mitochondrial biogenesis and protein synthesis.He is currently characterizing the interaction of NMDAR, PIN, and PnNOS in the central and peripheral neural circuits affecting the erectile response, and the role of androgens in the regulation of the levels of these proteins. Nitric oxide (NO) and reactive oxygen species (ROS) in the pathogenesis of Peyronieís disease: Since the balance between NO and ROS at the tissue level has been shown to play a fundamental role in normal wound healing and fibrotic processes, we have initiated a study of this interaction in the modulation of plaque formation in a rat model of Peyronieís disease and in invitro cultures of human tunica albuginea. We are also establishing a profile of gene expression associated with fibrosis.

Research Interest

Dr. Gonzalez-Cadavid has made significant research contributions in several fields of cellular and molecular biology approaches to pathophysiology. He focused initially on alterations of collagen deposition with aging, and later on mitochondrial biogenesis and protein synthesis. These studies evolved into the role of mitochondrial DNA and different oncogenes in tumor progression, and after joining the UCLA Department of Urology he focused on topics of urology relevance, mainly androgen dependence of penile growth and erectile function, and the effect of risk factors for erectile dysfunction, such as aging, diabetes, and smoking, on the nitric oxide/cGMP control of the erectile response.