Journal of Stem Cell Research & Therapy

Gang Pei

Publications

• Research Article
  In vivo Direct Reprogramming of Fibroblasts into Cardiomyocyte-Like Cells Though Inhibition of HDACs and TGF-β Pathway
  Author(s): Hua Li, Junbo Ge and Gang PeiHua Li, Junbo Ge and Gang Pei
  
  Background: Substantial progress has been recently achieved that direct lineage reprogramming induced by small molecule compounds was possible either in vitro or in vivo, which provided a promising cellular strategy for regenerative therapy. Method: A combination of an inhibitor of HDACs, valproic acid (V) and an inhibitor of TGF-β pathway, tranilast (T) were applied to identify the conversation of fibroblasts into induced cardiomyocyte-like cells (iCMs) in situ in mice with myocardial infarction. Result: We found that the combination of two small molecules, V&T could reprogram cardiac fibroblasts into iCMs in vivo, which were co-labeled with vimentin and a-actin 4 weeks after myocardial infarction; while, the phenomenon was found neither in mice with non-myocardial infarction nor in mice with myocardial infarction induced only by physiological saline. And furthermore, thes.. View More»
  DOI: 10.4172/2157-7633.1000373

  Abstract PDF