Journal of Bioequivalence & Bioavailability

Faisal Alotaibi F

Publications

• Research Article
  Development and Validation of A HPLC-UV Method for Dissolution Testing of Ciclosporin: Its Application to The Measurement of Brand and Generic Versions from Different Countries
  Author(s): Badr Aljohani, Faisal Alotaibi F, Essam Ghazaly, Jaber Al Jaber, David Perrett and Atholl Johnston Badr Aljohani, Faisal Alotaibi F, Essam Ghazaly, Jaber Al Jaber, David Perrett and Atholl Johnston
  
  Ciclosporin is used as an immunosuppressant in post-organ transplantation. Recently, many questions have been raised about using generic substitutes, especially with narrow therapeutic index drugs (NTIDs). In this study, a simple high-performance liquid chromatography (HPLC) method was developed, validated and applied to detection ciclosporin in dissolution testing. Seven ciclosporin products (gelatin capsules) were included in this study, obtained from Columbia (C), Egypt (E), India (I), Jordan (J), Pakistan (P), Saudi Arabia (S), and Turkey (T). The dissolution test was done for all capsules. The Conditions were as follows: 500 ml deionized water as the medium in apparatus 2 (Pharmatest, Germany), temperature 37.5 ± 0.5°C; 50 rev/min, sampling times were 5, 10, 15, 30, 60 and 90 min with 5 ml for each sample. HPLC separation was done by a C18 column, 5 μm, (4.6 ×.. View More»
  DOI: 10.4172/jbb.1000354

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