Journal of Stem Cell Research & Therapy

Ekaterina Y SheveZla

Publications

• Research Article
  Impaired Functions of Bone Marrow Mesenchymal Stromal Cells in Patients with Hematological Malignancies are Partially Improved by Fibroblast Growth Factor
  Author(s): Ekaterina Y SheveZla, Marina A Tikhonova, Egor V Batorov, Vera V Sergeevicheva, Irina V Kryuchkova, Vladimir A Kozlov, Alexandr A Ostanin and Elena R ChernykhEkaterina Y SheveZla, Marina A Tikhonova, Egor V Batorov, Vera V Sergeevicheva, Irina V Kryuchkova, Vladimir A Kozlov, Alexandr A Ostanin and Elena R Chernykh
  
  Mesenchymal stromal cells (MSCs) possess a multi-lineage potential and immunoregulatory activities which provides them a great potential in cell-oriented technologies. However, their biologic properties may be impaired in various pathologies, so approaches to improving the ability of MSCs to expand and express the expected immunoregulatory properties represent one of the challenges for this novel therapy. In the present study, we characterized bone marrow-derived MSC expansion along with their functional properties in patients with hematological malignancies, and designed a strategy of ex vivo pretreatment with the basic fibroblast growth factor (FGFb) to improve MSC activities. Our results demonstrated those patients MSCs are generally consistent with the Minimal criteria proposed by International Society for Cellular Therapy to design MSCs, and, moreover, possess a .. View More»
  DOI: 10.4172/2157-7633.1000137

  Abstract PDF