Desalegn Nega

Desalegn Nega
Malaria and other Vector-Borne Parasitic Diseases Research, Ethiopian Public Health Institute,
Addis Ababa
Ethiopia

Publications
  • Review Article
    Malaria Vaccine Development: Recent Advances alongside the Barriers
    Author(s): Desalegn Nega, Abebe Alemu and Geremew TasewDesalegn Nega, Abebe Alemu and Geremew Tasew

    Although malaria control efforts have currently reduced much of the morbidity and mortality, yet malaria remains a hard problem in many parts of Africa. Together with the existing malaria control efforts, an effective malaria vaccine is expected to act as an important weapon to fight against malaria burden. Developing an efficacious malaria vaccine is a top priority in the agenda of global health program. However, the multi-stage life cycle, antigenic variation, and vast genetic diversity of malaria parasites made malaria vaccine development difficult for years. This study was conducted with the aim of reviewing the status of malaria vaccine development through different obstacles in the path. Vaccine trials currently upgraded to yield a partially effective and short-lived immunity with the pre-erythrocytic subunit vaccine, RTS,S/AS01, which is likely to be the first vaccine to be lic.. View More»
    DOI: 10.4172/2155-9597.1000300

    Abstract PDF