Journal of Stem Cell Research & Therapy

David Fletcher

Publications

• Research Article
  Mesenchymal Stem Cell Soluble Mediators and Cystic Fibrosis
  Author(s): Morgan T Sutton, David Fletcher, Nicole Episalla, Lauren Auster, Michael Folz, Varun Roy, Rolf van Heeckeren, Donald P Lennon, Arnold I Caplan and Tracey L BonfieldMorgan T Sutton, David Fletcher, Nicole Episalla, Lauren Auster, Michael Folz, Varun Roy, Rolf van Heeckeren, Donald P Lennon, Arnold I Caplan and Tracey L Bonfield
  
  Human Mesenchymal stem cells (hMSCs) secrete products (supernatants) that are anti-inflammatory and antimicrobial. We have previously shown that hMSCs decrease inflammation and Pseudomonas aeruginosa infection in the in vivo murine model of Cystic Fibrosis (CF). CF is a genetic disease in which pulmonary infection and inflammation becomes the major cause of morbidity and mortality. Our studies focus on determining how hMSCs contribute to improved outcomes in the CF mouse model centering on how the hMSCs impact the inflammatory response to pathogenic organisms. We hypothesize that hMSCs secrete products that are anti-inflammatory in scenarios of chronic pulmonary infections using the murine model of infection and inflammation with a specific interest in Pseudomonas aeruginosa (gram negative). Further, our studies will identify whether the hMSCs are impacting this inflamma.. View More»
  DOI: 10.4172/2157-7633.1000400

  Abstract PDF