Journal of Stem Cell Research & Therapy

Damour O

Publications

• Research Article
  Long-Term Results of Cultured Autologous Oral Mucosa Epithelial Cell-Sheet (CAOMECS) Graft for the Treatment of Blindness Due to Bilateral Limbal Stem Cell Deficiency
  Author(s): Kocaba V, Thépot A, Yamato M, Daisuke M, Kellal M, Mojallal A, Damour O and Burillon CKocaba V, Thépot A, Yamato M, Daisuke M, Kellal M, Mojallal A, Damour O and Burillon C
  
  Purpose: To treat bilateral corneal blindness due to limbal stem cell deficiency (LSCD) thanks to corneal transplant of an autologous epithelium of stem cells cultivated by the oral mucous membrane by the technology UpCell®-Insert (CAOMECS for Cultured Autologous Oral Mucosal Epithelial Cell-Sheet). Methods: The efficacy of a CAOMECS corneal graft was assessed over the long term for 23 out of 26 eyes presenting severe bilateral LSCD. This study follows a clinical trial evaluated, which lasted for 12 months. The major evaluation criterion was visual acuity and the minor criteria were the condition of the epithelium (a composite criterion assessed by grading superficial punctate keratitis, the presence of ulcer, the number and activity of neovessels and the presence of conjunctivalization) and the quality of life (grading of photophobia, dryness and pain). The mean follow-up was of .. View More»
  DOI: 10.4172/2157-7633.1000181

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