Journal of Clinical & Experimental Pharmacology

Cunha Leal PD

Publications

• Research Article
  Evaluation of Morphine Effect on Tumor Growth in Mice
  Author(s): Santana Huang AP, Rey Moura EC, Cunha Leal PD, Bogéa Serra ICP, Fernandes do Nascimento FR and Sakata RKSantana Huang AP, Rey Moura EC, Cunha Leal PD, Bogéa Serra ICP, Fernandes do Nascimento FR and Sakata RK
  
  Background and objectives: The role of opioids on tumor growth is widely discussed. The aim of this study was to analyze whether morphine has a direct influence on tumor growth. Methods: Twenty mice received intraperitoneal inoculation of Ehrlich tumor cells and were divided into two groups. Morphine group received 10 mg/kg, and the control group received 0.9% saline solution, once daily for 7 days, by gavage of 10 ml/kg. On the tenth day, 5 animals were sacrificed, and 5 were evaluated for survival in each group. The following were evaluated: survival; abdominal circumference; ascites volume; weight; tumor cells in ascites; lymphocytes in the spleen, inguinal and mesenteric lymph nodes and bone marrow; cytokines in ascites, serum, lymph nodes and spleen; nitric oxide (NO) in ascites and spleen; nitrite in ascites; arginase in ascites; superoxide dismutase (SOD) in ascites; and immuno.. View More»
  DOI: 10.4172/2161-1459.1000249

  Abstract PDF