Journal of Blood Disorders & Transfusion

Claudia Regina Bonini-Domingos

Publications

• Research Article
  The Mean Corpuscular Volume and Hydroxyurea in Brazilian Patients with Sickle Cell Anemia: A Surrogate Marker of Compliance
  Author(s): Ana Maria Mach Queiroz, Clarisse Lopes de Castro Lobo, Emilia Matos do Nascimento, Basilio de Bragança Pereira, Claudia Regina Bonini-Domingos, Gilberto Perez Cardoso and Samir K BallasAna Maria Mach Queiroz, Clarisse Lopes de Castro Lobo, Emilia Matos do Nascimento, Basilio de Bragança Pereira, Claudia Regina Bonini-Domingos, Gilberto Perez Cardoso and Samir K Ballas
  
  The suppression of erythropoiesis by Hydroxyurea (HU) therapy is associated with increase in mean corpuscular volume, in addition to the increase in Hb F. Monitoring the mean corpuscular volume values and the presence of macrocytosis are effective tools of adherence to the treatment with HU in patients with sickle cell anemia. The aim of this study is to monitor the mean corpuscular volume values after starting treatment with HU to determine if macrocytosis can be used as a surrogate marker of compliance with therapy. We conducted a prospective cohort study over one year with measurements of blood counts and mean corpuscular volume after starting therapy with HU in 95 patients with sickle cell anemia who were regularly followed in our ambulatory outpatient unit. In one-year of successful use of HU the mean value of the mean corpuscular volume increased significantly. The Andersen and .. View More»
  DOI: 10.4172/2155-9864.1000157

  Abstract PDF