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Christiane Willhelm
Christiane Willhelm
Germany
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Research Article
Systematic Cochrane Reviews in Neonatology: A Critical Appraisal
Author(s): Christiane Willhelm, Wolfgang Girisch, Sven Gottschling, Stefan Gräber and Sascha MeyerChristiane Willhelm, Wolfgang Girisch, Sven Gottschling, Stefan Gräber and Sascha Meyer
Background: There is a lack of up-to-date, systematic reviews that critically assess the role and potential limitations of Evidence based medicine (EBM) and systematic reviews in neonatology. Methods: We performed a systematic literature review of all Cochrane Reviews published between 1996 and 2010 by the Cochrane Neonatal Review Group (CNRG). Main outcome parameter: Assessment of the percentage of reviews that concluded that a certain intervention provides a benefit, percentage of reviews that concluded that no benefit was seen, and percentage of studies that concluded that the current level of evidence is inconclusive. Results: In total, 262 reviews were enrolled, most of which included exclusively preterm infants (146/262). The majority of reviews assessed pharmacological interventions (145/262); other important fields included nutr.. View More»
DOI: 10.4172/2167-0897.1000106