Journal of Stem Cell Research & Therapy

Ching-Chang Ko

Publications

• Research Article
  Dopaminergic Enhancement of Cellular Adhesion in Bone Marrow Derived Mesenchymal Stem Cells (MSCs)
  Author(s): Si Chen, Bing Bai, Dong Joon Lee, Shannon Diachina, Yina Li, Sing Wai Wong, Zhengyan Wang, Henry CTseng and Ching-Chang KoSi Chen, Bing Bai, Dong Joon Lee, Shannon Diachina, Yina Li, Sing Wai Wong, Zhengyan Wang, Henry CTseng and Ching-Chang Ko
  
  Dopamine (DA) is a well-known neurotransmitter and critical element in the mussel adhesive protein that has gained increasing attention for its role in cellular growth enhancement in biomaterials, including cellular adhesion improvement. As the mechanism underlying this remains unclear, the objective of this study was to explore the effects of DA on the adhesion properties of bone marrow derived rat mesenchymal stem cells (rMSCs) using an hydroxyapatite-gelatin nanocomposite biomaterial and to test whether the effects are mediated through various endogenously expressed DA receptors. Primary rMSCs were pretreated with D1-like antagonist, D2-like antagonist, or a combination of these antagonists followed by treatment with 50 μM DA and cellular adhesion quantification at 0.5, 1, 2 and 4 hours post DA addition. DA was found to increase rMSC adhesion and spreading at the 0.5 hour time-p.. View More»
  DOI: 10.4172/2157-7633.1000395

  Abstract PDF