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Chalal N

Chalal N


  • Research Article
    Frequency of Factor II G20210A and Factor V Leiden Mutations in Algerian Patients with Venous Thromboembolism
    Author(s): Chalal N, Demmouche A and Cherif touil SChalal N, Demmouche A and Cherif touil S

    Several inherited polymorphisms are associated with the risk of venous thrombosis, including mutation at codon 506 of the factor V gene and mutation at position 20210 of the prothrombin gene. The aim of this study was to determine the frequency of factor II G20210A and factor V Leiden mutations in Algerian patients with venous thromboembolism disease. In this study, genotyping for factor V Leiden and factor II G20210A mutations was performed in 40 patients with venous thrombosis by the GeneXpert Dx. According to the results of the study, factor V Leiden was detected in 5 patients (12.5%) and factor II G20210A was detected in only one patient (2.5%). Both mutations were found in heterozygous form and no patient was double heterozygous. In conclusion, the prevalence of factor V Leiden mutation was high among Algerian patients with venous thromboembolism disease however, further studies .. Read More»
    DOI: 10.4172/2155-9864.1000247

    Abstract PDF