Journal of Microbial & Biochemical Technology

Cesare Formisano

Publications

• Research Article
  Auto-Modification of Poly (ADP-Ribose) Polymerase and Membrane Lipid Composition as Diagnostic Tools to Measure the Physio-Pathological State of the Cell
  Author(s): Anna Rita Bianchi, Simona Ruggiero, Cesare Formisano, Giuseppe Galloro, Anna De Maio, Carla Ferreri and Maria Rosaria Faraone MennellaAnna Rita Bianchi, Simona Ruggiero, Cesare Formisano, Giuseppe Galloro, Anna De Maio, Carla Ferreri and Maria Rosaria Faraone Mennella
  
  Poly(ADPribosyl)ation, catalysed by poly(ADP-ribose)polymerases, affects many cellular events and has a recognized epigenetic role. Nuclear poly(ADP-ribose)polymerases 1 and 2 are hyper activated by DNA strandbreaks. They auto-modify with large polymers of ADP-ribose and recruit DNA repair proteins. The more the DNA strand-breaks, the more poly(ADP-ribose) polymerase modifies itself. On the other hand, dietary lipids can be signaling molecules, lead to pro-(ω6)/ anti-(ω3) inflammatory compounds, and be included in biomembranes, good biomarkers of their unbalance. Here, we report the results obtained from an epidemiological study to establish whether the combination of two different analyses, i.e. detecting auto-modified poly (ADP-ribose) polymerase levels and analyzing erythrocyte membrane fatty acid composition, might help to monitor the physio-pathological state of the c.. View More»
  DOI: 10.4172/1948-5948.1000148

  Abstract PDF