Journal of Blood Disorders & Transfusion

Carl-Johan Jakobsen

Publications

• Research Article
  Perioperative Administration of Fibrinogen is Associated with Increased Risk of Postoperative Thromboembolic Complications after Cardiac Surgery
  Author(s): Carl-Johan Jakobsen, Mariann Tang and Lars Folkersen Carl-Johan Jakobsen, Mariann Tang and Lars Folkersen
  
  Introduction: Fibrinogen is a key protein in achieving and maintaining haemostasis. Prophylactic fibrinogen has been shown to reduce bleeding after coronary artery bypass graft (CABG) and studies have reported an inverse correlation between preoperative plasma concentration of fibrinogen and the volume of postoperative bleeding after CABG. This indicates that preoperative fibrinogen plasma concentration, even within the normal range, is a limiting factor for haemostasis after cardiac surgery. In theory, fibrinogen might induce a risk for thrombosis and hypercoagulability. The reported adverse effects of fibrinogen administration are few, without clinical significance or blurred by the use of other medications influencing coagulation; the potential adverse effects of prophylactic fibrinogen on larger groups of cardiac surgery patients seem unidentified. .. View More»
  DOI: 10.4172/2155-9864.S1-004

  Abstract PDF