Journal of Biomolecular Research & Therapeutics

Ayaz Mahmood Dar

Biography

During the research period i learned multi-stepped organic synthesis of highly condensed heterocyclic compounds like pyrimidines, pyrans, benzothiazines, pyrazoles, pyrazolones, oxadiazoles, thiazoles, oxadiazinanones, etc in the field of organic chemistry. I worked on IR, H NMR, 13C NMR, DEPT, MS, CHN Analysis. The synthesis was lead by different protocols like one-pot, multi-component, etc. Antimicrobial studies against different bacterial and fungal strains, Toxicity (MTT assay, sulforhodamine B Assay) against different cancer cell and non-cancer cells, genotoxic role (comet assay), computational profiling (PAAS software to predict the bioactivity), physicochemical properties (Gold score analysis, Algorithm of activity spectrum estimation) DNA binding profile heterocyclic compounds, gel electrophoroetic studies, Molecular docking/ modelling studies with DNA, proteins like S 12, P 53 tumour suppressor protein and enzymes like DNA-TOPO-1, study the cleavege supercoiled pBR322 DNA via ROS generation pathway, T4 DNA ligase assay, opitical behaviour and nano characteristics of heterocycles like pyrazolones. For my future research career, I look forward to learn more about the interesting opportunities and exploring how it will fit with my past experiences. In other words, I am in search of a position where I could broaden my knowledge and scientific activity in basic as well as applied science. 

Research Interest

Research in the areas medicinal chemistry, molecular manipulations of small molecules in biological systems.