Journal of Allergy & Therapy

Andrew Pham

Publications

• Research Article
  No Correlation between Beta2-Adrenergic Receptor Polymorphisms and the Severity and Clinical Control of Geriatric Asthma and COPD
  Author(s): Inderpal Randhawa, Andrew Pham, William Klaustermeyer and Joseph YusinInderpal Randhawa, Andrew Pham, William Klaustermeyer and Joseph Yusin
  
  Background: Polymorphisms of the β2-adrenergic receptor (ADRB2) have previously been associated with non-specific bronchial hyper-responsiveness, adverse response to β2-agonists and variable effects on lung function. The objective of this study was to determine whether genotypic variance in ADRB2 polymorphisms in a cohort of geriatric men and women with asthma and/or COPD correlate with disease severity, baseline pulmonary function, and the ability to maintain clinical control of their disease. Methods: This comparative, prospective cohort study sequenced two ADRB2 polymorphisms, Arg16 --> Gly and Gln27 --> Glu, in 103 geriatric patients with a clinical history of asthma and/or COPD. Primary endpoints included pulmonary exacerbation rate, hospitalization rate, and quality of life scores. Results: Arg/Arg genotype comprised 13.6% of the cohort. No si.. View More»
  DOI: 10.4172/2155-6121.1000196

  Abstract PDF