Modern Chemistry & Applications

Amoyaw PNA

Publications

• Research Article
  Evaluation of the Physicochemical Properties of a Novel Antimalarial Drug Lead, Cyclen Bisquinoline
  Author(s): Mohammad Faisal Hossain1,2, Amoyaw PNA1, Hardeep S Saluja1 and MO Faruk Khan 1,2*Mohammad Faisal Hossain1,2, Amoyaw PNA1, Hardeep S Saluja1 and MO Faruk Khan 1,2*
  
  The purpose of this study was to evaluate physicochemical properties of an antimalarial drug lead, 4,10-bis(7- chloroquinoline)-1,4,7,10-tetraazacyclododecane (Cyclenbisquinoline; CNBQ) and its hydrochloride salt. The free base (FB) of CNBQ is a white polymorphic crystalline powder and the salt is off-white powder. The application of standard experimental protocol including differential scanning calorimetric (DSC) analyses revealed that the FB has at least four different crystalline polymorphs melting at 166°C, 178°C, 195°C and 234°C, respectively, and the salt showed a broad endotherm, suggesting it to be amorphous in nature. Equilibrium solubility and stability of both FB and salt were carried out in different mediums, and samples were analyzed using reverse phase-high performance liquid chromatography (RP-HPLC). The compound is highly hydrophobic; however, salt .. View More»
  DOI: 10.4172/2329-6798.1000181

  Abstract PDF