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Alireza Shoae-Hassani
Alireza Shoae-Hassani
School of Advanced Technologies in Medicine,
Tehran
West Indies
Publications
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Review Article
Safe Transplantation Of Pluripotent Stem Cell By Preventing Teratoma Formation
Author(s): Rashin Mohseni, Amir Ali Hamidieh, Javad Verdi and Alireza Shoae-HassaniRashin Mohseni, Amir Ali Hamidieh, Javad Verdi and Alireza Shoae-Hassani
As the renewable source of all cell types in the human body, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine and cell therapy. However, one major obstacle to the clinical application of these pluripotent stem cells (PSCs) is that these kinds of stem cells remaining with their differentiated derivatives pose cancer risk by forming teratomas after transplantation. The microenvironment niches of PSCs are crucial for teratoma formation and its progression. The high expression of some oncogenes like cMyc and Klf4 are involved in the teratoma formation process. The kinetics of the teratoma and tumor formation after transplantation is depends on the number of remaining PSCs and it could take a long time for a small number of PSCs to form teratomas. Therefore, the batch-to-batch deviation in .. View More»
DOI: 10.4172/2157-7633.1000212