The aim of this study was to observe the change in nail shape especially lunula in asthmatic, diabetic and tuberculosis patients. This study was performed at Bahawal Victoria Hospital (BVH), Punjab and Pakistan. The hospital was visited daily and studied the patients there from April, 2016 to May, 2016. Total 50 patients from each disease i.e., asthma, diabetes and tuberculosis were selected. The nail of different patients were observed and studied. There was also a control group. The control group contained healthy persons. Results were evaluated by comparing the groups with control group. It was observed that the persons having lunula on their nails are an indicator of good thyroid health and digestion. Such persons have very active immune system.