Plants are utilized as a cheap, safe, and efficacious production platform for vaccines and other therapeutic proteins in lowincome countries that do not have access to modern medicine. A simple way to rapidly produce high-level pharmaceutical proteins in plants is to use plant virus expression vectors because their genomes are small and easily manipulated. This study discusses several plant expression systems based on geminiviruses that have been widely developed for vaccine generation and other industrial proteins, as well as recent advances in this field are also presented. Most plant viruses that have been engineered as expression vectors to generate vaccines and other pharmaceutical proteins have RNA-positive genomes, and DNA-based viral vectors are less commonly used because their genomes have a restricted capacity to carry foreign genes. However, the developments of deconstructed vectors have recently led to rapid advances using plant DNA viruses for protein expression. This study discusses the latest progressions in geminiviral expression systems and their use in the production of pharmaceutical proteins.
Published Date: 2022-07-07; Received Date: 2022-06-06