Oral Health and Dental Management

Abstract

Oxidative Stress in Oral Submucous Fibrosis- A Clinical and Biochemical Study

Chandni Shekhawat, Subhas Babu, R Gopakumar, Shishir Shetty, Arshdeep K Randhawa, Hemant Mathur, Aditi Mathur, Hersheal Aggarwal

Background and Objectives: A Biochemical study was undertaken to determine the effect of betel quid chewing on serum and salivary total antioxidant capacity (TAC) in Oral sub mucous fibrosis(OSMF) patients and its association with duration and frequency of habit. Methodology: The study consisted of four groups, one control and three study groups, each with 15 subjects. Thorough intraoral examination was done for all the groups. Salivary and serum samples were collected from all the groups, which were further subjected for biochemical analysis. The observations of the study were subjected to statistical analysis and the results were tabulated. Results and Conclusion: The level of salivary and serum TAC decreases secondary to betel quid chewing in OSMF patients. TAC values, both in saliva and serum showed negative correlation with duration and frequency of habit in OSMF patients. As the severity of OSMF increases, the level of TAC decreases.