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Abstract
Nanoparticle Based Delivery of miRNAs to Overcome Drug Resistance in Breast Cancer
Serap Yalcin and Gunduz U
Nanoparticle-based targeted drug delivery is a successful strategy to overcome the side effect of chemotherapy. Nanoparticles based drug delivery systems that have been designed to enhance delivery of therapeutics to tumors, are a novel approach. Nanoparticles have reactive surface that can be readily modified with biocompatible coatings and loaded with therapeutic agents (miRNA, siRNA, antibody, anti-cancer drug etc..). MicroRNAs (miRNAs or miRs) are short non-coding RNAs which posttranscriptionally regulate growth, differentiation, apoptosis, motility, and malignant transformation. In addition, some miRNAs have been classified as proto-oncogenes. The levels of changed miRNA expression play significant role in the initiation of many diseases, including cancer, especially tumor progression and metastasis. Further studies, miRNA conjugation to drug carrier systems is used to target to cancer cells. In this review, we focus on miRNA carrier nanoparticles, and summarize novel advances about their use in drug resistance breast cancer therapy.